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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Doerflinger, Marcel; Deng, Yexuan; Whitney, Paul; Salvamoser, Ranja; Engel, Sven; Kueh, Andrew J; Tai, Lin; Bachem, Annabell; Gressier, Elise; Geoghegan, Niall D; Wilcox, Stephen; Rogers, Kelly L; Garnham, Alexandra L; Dengler, Michael A; Bader, Stefanie M; Ebert, Gregor; Pearson, Jaclyn S; De Nardo, Dominic; Wang, Nancy; Yang, Chenying; Pereira, Milton; Bryant, Clare E; Strugnell, Richard A; Vince, James E; Pellegrini, Marc; Strasser, Andreas; Bedoui, Sammy; Herold, Marco J.
Afiliación
  • Doerflinger M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Deng Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
  • Whitney P; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Salvamoser R; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Engel S; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Tai L; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Bachem A; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Gressier E; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Geoghegan ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Rogers KL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Garnham AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Dengler MA; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Bader SM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Ebert G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Research, Monash University, Clayton, VIC, Australia; Department of Microbiology, Monash University, Clayton, VIC, Australia.
  • De Nardo D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Wang N; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Yang C; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Pereira M; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA; University of Cambridge, Cambridge, UK.
  • Bryant CE; University of Cambridge, Cambridge, UK.
  • Strugnell RA; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia.
  • Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Pellegrini M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Strasser A; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. Electronic address: strasser@wehi.edu.au.
  • Bedoui S; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC, Australia. Electronic address: sbedoui@unimelb.edu.au.
  • Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. Electronic address: herold@wehi.edu.au.
Immunity ; 53(3): 533-547.e7, 2020 09 15.
Article en En | MEDLINE | ID: mdl-32735843
Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection, we infected mice and macrophages deficient for diverse combinations of caspases-1, -11, -12, and -8 and receptor interacting serine/threonine kinase 3 (RIPK3). Loss of pyroptosis, caspase-8-driven apoptosis, or necroptosis had minor impact on Salmonella control. However, combined deficiency of these cell death pathways caused loss of bacterial control in mice and their macrophages, demonstrating that host defense can employ varying components of several cell death pathways to limit intracellular infections. This flexible use of distinct cell death pathways involved extensive cross-talk between initiators and effectors of pyroptosis and apoptosis, where initiator caspases-1 and -8 also functioned as executioners when all known effectors of cell death were absent. These findings uncover a highly coordinated and flexible cell death system with in-built fail-safe processes that protect the host from intracellular infections.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Salmonella / Infecciones por Salmonella / Apoptosis / Piroptosis / Necroptosis / Macrófagos Límite: Animals Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Salmonella / Infecciones por Salmonella / Apoptosis / Piroptosis / Necroptosis / Macrófagos Límite: Animals Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia