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Prenylated Flavonoids from the Roots of Tephrosia rhodesica.
Atilaw, Yoseph; Muiva-Mutisya, Lois; Bogaerts, Jonathan; Duffy, Sandra; Valkonen, Arto; Heydenreich, Matthias; Avery, Vicky M; Rissanen, Kari; Erdélyi, Máté; Yenesew, Abiy.
Afiliación
  • Atilaw Y; Department of Chemistry, University of Nairobi, 30197-00100, Nairobi, Kenya.
  • Muiva-Mutisya L; Department of Chemistry-BMC, Uppsala University, P.O. Box 756, SE-751 23 Uppsala, Sweden.
  • Bogaerts J; Department of Chemistry, University of Nairobi, 30197-00100, Nairobi, Kenya.
  • Duffy S; Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
  • Valkonen A; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Qld 4111, Australia.
  • Heydenreich M; University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 Jyväskylä, Finland.
  • Avery VM; Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany.
  • Rissanen K; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Qld 4111, Australia.
  • Erdélyi M; University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 Jyväskylä, Finland.
  • Yenesew A; Department of Chemistry-BMC, Uppsala University, P.O. Box 756, SE-751 23 Uppsala, Sweden.
J Nat Prod ; 83(8): 2390-2398, 2020 08 28.
Article en En | MEDLINE | ID: mdl-32790306
ABSTRACT
Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (11) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 µg and IC50 = 5-15 µM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Flavonoides / Raíces de Plantas / Tephrosia Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article País de afiliación: Kenia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Flavonoides / Raíces de Plantas / Tephrosia Idioma: En Revista: J Nat Prod Año: 2020 Tipo del documento: Article País de afiliación: Kenia