Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-&#954;B/NLRP3 inflammasome and sirtuin 1/autophagy axis.

Yang, Shin-Ruen; Hsu, Wan-Han; Wu, Chung-Yao; Shang, Hung-Sheng; Liu, Feng-Cheng; Chen, Ann; Hua, Kuo-Feng; Ka, Shuk-Man

Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis.

Yang, Shin-Ruen; Hsu, Wan-Han; Wu, Chung-Yao; Shang, Hung-Sheng; Liu, Feng-Cheng; Chen, Ann; Hua, Kuo-Feng; Ka, Shuk-Man.

Afiliación

Yang SR; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Hsu WH; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wu CY; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Shang HS; Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Liu FC; Division of Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen A; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Hua KF; Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Ka SM; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

FASEB J ; 34(10): 13284-13299, 2020 10.

Article en En | MEDLINE | ID: mdl-32813287

Asunto(s)

Antiinflamatorios/uso terapéutico; Autofagia; Compuestos de Bifenilo/uso terapéutico; Inflamasomas/metabolismo; Lignanos/uso terapéutico; Nefritis Lúpica/tratamiento farmacológico; FN-kappa B/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Animales; Células Cultivadas; Femenino; Inflamasomas/efectos de los fármacos; Riñón/efectos de los fármacos; Riñón/metabolismo; Nefritis Lúpica/metabolismo; Ratones; Especies Reactivas de Oxígeno/metabolismo; Sirtuina 1/metabolismo; Linfocitos T/efectos de los fármacos

Palabras clave

NLRP3 inflammasome; accelerated; autophagy; honokiol; severe lupus nephritis; sirtuin 1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Compuestos de Bifenilo / Nefritis Lúpica / FN-kappa B / Lignanos / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán

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