The second messenger c-di-AMP mediates bacterial exopolysaccharide biosynthesis: a review.
Mol Biol Rep
; 47(11): 9149-9157, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-33128205
ABSTRACT
Cyclic dimeric adenosine 3'-5'-monophosphate (c-di-AMP) is a recently discovered nucleotide messenger in bacteria. It plays an important role in signaling, transcription, and cell physiology, such as in bacterial growth, potassium transport, fatty acid synthesis, the metabolic balance of cell wall components, and biofilm formation. Exopolysaccharides (EPSs) have distinct physico-chemical properties and diverse bioactivities including antibacterial, hypolipidemic, and antioxidative activities, and they are widely used in the food, pharmaceutical, and cosmetic industries. Although c-di-AMP has been demonstrated to regulate the biosynthesis of bacterial EPSs, only a single c-di-AMP receptor, CabpA, has been identified in EPS synthesis. With the aim of describing current understanding of the regulation of microbial EPSs, this review summarizes c-di-AMP biosynthesis and degradation as well as the mechanism through which c-di-AMP regulates bacterial EPSs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos Bacterianos
/
Bacterias
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Fosfatos de Dinucleósidos
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Sistemas de Mensajero Secundario
Idioma:
En
Revista:
Mol Biol Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
China