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An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline.
Trzeciakiewicz, Hanna; Ajit, Deepa; Tseng, Jui-Heng; Chen, Youjun; Ajit, Aditi; Tabassum, Zarin; Lobrovich, Rebecca; Peterson, Claire; Riddick, Natallia V; Itano, Michelle S; Tripathy, Ashutosh; Moy, Sheryl S; Lee, Virginia M Y; Trojanowski, John Q; Irwin, David J; Cohen, Todd J.
Afiliación
  • Trzeciakiewicz H; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599-7260, USA.
  • Ajit D; Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Tseng JH; Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Chen Y; Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Ajit A; Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Tabassum Z; Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Lobrovich R; Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-4283, USA.
  • Peterson C; Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-4283, USA.
  • Riddick NV; Division of Comparative Medicine, University of North Carolina, Chapel Hill, NC, 27599-7146, USA.
  • Itano MS; Department of Cell Biology and Physiology, Carolina Institute for Developmental Disabilities, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599-7250, USA.
  • Tripathy A; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599-7260, USA.
  • Moy SS; Department of Psychiatry, Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, 27599-7146, USA.
  • Lee VMY; Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-4283, USA.
  • Trojanowski JQ; Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-4283, USA.
  • Irwin DJ; Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104-4283, USA.
  • Cohen TJ; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599-7260, USA. toddcohen@neurology.unc.edu.
Nat Commun ; 11(1): 5522, 2020 11 02.
Article en En | MEDLINE | ID: mdl-33139698
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas tau / Tauopatías / Disfunción Cognitiva / Histona Desacetilasa 6 Tipo de estudio: Screening_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas tau / Tauopatías / Disfunción Cognitiva / Histona Desacetilasa 6 Tipo de estudio: Screening_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos