Targeted epigenetic modulation using a DNA-based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells.

Lee, Jin-A; An, Jieun; Taniguchi, Junichi; Kashiwazaki, Gengo; Pandian, Ganesh N; Parveen, Nazia; Kang, Tong Mook; Sugiyama, Hiroshi; De, Debojyoti; Kim, Kyeong Kyu

Lee, Jin-A; An, Jieun; Taniguchi, Junichi; Kashiwazaki, Gengo; Pandian, Ganesh N; Parveen, Nazia; Kang, Tong Mook; Sugiyama, Hiroshi; De, Debojyoti; Kim, Kyeong Kyu.

Afiliación

Lee JA; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
An J; Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
Taniguchi J; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto, Japan.
Kashiwazaki G; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto, Japan.
Pandian GN; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto, Japan.
Parveen N; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
Kang TM; Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto, Japan.
De D; Department of Biotechnology, National Institute of Technology, Durgapur, Burdwan, West Bengal, India.
Kim KK; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

J Cell Physiol ; 236(5): 3946-3962, 2021 05.

Article en En | MEDLINE | ID: mdl-33164232

Asunto(s)

ADN/metabolismo; Epigénesis Genética; Inhibidores de Histona Desacetilasas/farmacología; Células Madre Embrionarias de Ratones/citología; Miocitos Cardíacos/citología; Organogénesis; Animales; Biomarcadores/metabolismo; Diferenciación Celular/efectos de los fármacos; Cuerpos Embrioides/efectos de los fármacos; Cuerpos Embrioides/metabolismo; Endodermo/metabolismo; Epigénesis Genética/efectos de los fármacos; Células HEK293; Humanos; Imidazoles/farmacología; Mesodermo/metabolismo; Ratones; Modelos Biológicos; Células Madre Embrionarias de Ratones/efectos de los fármacos; Células Madre Embrionarias de Ratones/metabolismo; Miocitos Cardíacos/efectos de los fármacos; Miocitos Cardíacos/metabolismo; Motivos de Nucleótidos/genética; Nylons/farmacología; Pirroles/farmacología; ARN Mensajero/genética; ARN Mensajero/metabolismo; Transcripción Genética/efectos de los fármacos

Palabras clave

cardiomyogenesis; embryonic stem cells; epigenetic switches; histone deacetylase inhibitor; pyrrole-imidazole polyamide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / Miocitos Cardíacos / Organogénesis / Epigénesis Genética / Inhibidores de Histona Desacetilasas / Células Madre Embrionarias de Ratones Límite: Animals / Humans Idioma: En Revista: J Cell Physiol Año: 2021 Tipo del documento: Article

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