Paternal bloodlines sculpting seminal concepts: circulating factors as mediators of transgenerational 'epigenopathy' and 'epigenetic resilience'.
EMBO J
; 39(23): e107014, 2020 12 01.
Article
en En
| MEDLINE
| ID: mdl-33175448
ABSTRACT
Accumulating evidence, particularly from rodent and human studies, shows that the environmental exposures and experience of a father prior to conception can modulate sperm epigenetics and subsequent offspring phenotypes. In this issue of The EMBO Journal, van Steenwyk and colleagues (2020) provide important new insights into how one form of paternal experience (early-life stress or trauma) may impact sperm epigenetics via circulating factors, presenting novel experimental evidence from a mouse model and an analogous human cohort.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Padre
/
Epigenómica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
EMBO J
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia