A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions.

Türk, Denise; Hanke, Nina; Lehr, Thorsten

Türk, Denise; Hanke, Nina; Lehr, Thorsten.

Afiliación

Türk D; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Hanke N; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Lehr T; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.

Pharmaceutics ; 12(11)2020 Nov 10.

Article en En | MEDLINE | ID: mdl-33182761

Palabras clave

cytochrome P450 2C8 (CYP2C8); drugdrug interaction (DDI); multidrug and toxin extrusion protein (MATE); organic cation transporter (OCT); physiologically-based pharmacokinetic (PBPK) modeling; trimethoprim

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmaceutics Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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