Chloroquine reverses chemoresistance via upregulation of p21<sup>WAF1/CIP1</sup> and autophagy inhibition in ovarian cancer.

Hwang, Jae Ryoung; Kim, Woo Young; Cho, Young-Jae; Ryu, Ji-Yoon; Choi, Jung-Joo; Jeong, Soo Young; Kim, Myeong-Sun; Kim, Ji Hye; Paik, E Sun; Lee, Yoo-Young; Han, Hee-Dong; Lee, Jeong-Won

Chloroquine reverses chemoresistance via upregulation of p21^WAF1/CIP1 and autophagy inhibition in ovarian cancer.

Hwang, Jae Ryoung; Kim, Woo Young; Cho, Young-Jae; Ryu, Ji-Yoon; Choi, Jung-Joo; Jeong, Soo Young; Kim, Myeong-Sun; Kim, Ji Hye; Paik, E Sun; Lee, Yoo-Young; Han, Hee-Dong; Lee, Jeong-Won.

Afiliación

Hwang JR; Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. jhwang1@skku.edu.
Kim WY; Department of Obstetrics & Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Cho YJ; Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Ryu JY; Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Choi JJ; Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Jeong SY; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kim MS; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kim JH; Department of Obstetrics and Gynecology, Dankook University College of Medicine, Cheonan, Chungnam, Republic of Korea.
Paik ES; Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Lee YY; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Han HD; Department of Immunology, School of Medicine, Konkuk University, Chungju, Republic of Korea.
Lee JW; Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. garden.lee@samsung.com.

Cell Death Dis ; 11(12): 1034, 2020 12 04.

Article en En | MEDLINE | ID: mdl-33277461

Asunto(s)

Autofagia/genética; Cloroquina/uso terapéutico; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Resistencia a Antineoplásicos/genética; Neoplasias Ováricas/tratamiento farmacológico; Neoplasias Ováricas/patología; Regulación hacia Arriba/genética; Animales; Proteínas de la Ataxia Telangiectasia Mutada/antagonistas & inhibidores; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Autofagia/efectos de los fármacos; Carcinoma Epitelial de Ovario/tratamiento farmacológico; Carcinoma Epitelial de Ovario/genética; Carcinoma Epitelial de Ovario/patología; Ciclo Celular/efectos de los fármacos; Muerte Celular/efectos de los fármacos; Línea Celular Tumoral; Cloroquina/farmacología; Cisplatino/farmacología; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Daño del ADN; Resistencia a Antineoplásicos/efectos de los fármacos; Femenino; Humanos; Ratones Endogámicos BALB C; Ratones Desnudos; Neoplasias Ováricas/genética; Transducción de Señal/efectos de los fármacos; Carga Tumoral/efectos de los fármacos; Regulación hacia Arriba/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Autofagia / Regulación hacia Arriba / Cloroquina / Resistencia a Antineoplásicos / Inhibidor p21 de las Quinasas Dependientes de la Ciclina Límite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Año: 2020 Tipo del documento: Article

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