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Cytotoxic Diterpenoids from Euphorbia fischeriana.
Meng, Jia; Li, Bo-Ting; Sheng, Gang; Zhang, An-Ling; Li, Xing-Cong; Tian, Jun-Mian.
Afiliación
  • Meng J; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
  • Li BT; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
  • Sheng G; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
  • Zhang AL; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
  • Li XC; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
  • Tian JM; Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, P. R. China.
Chem Biodivers ; 18(2): e2000919, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33354895
ABSTRACT
Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Their chemical structures and absolute configurations were determined by interpretation of NMR, HR-ESI-MS, ECD and X-ray diffraction data. Euphorfischerin A showed cytotoxicity against the human cancer cell lines HeLa, H460 and Namalwa with IC50 values of 4.6, 11.5 and 16.4 µM, respectively, while euphorfischerin B gave comparable IC50 values of 9.5, 17.4 and 13.3 µM against the three cancer cell lines, respectively.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Euphorbia / Diterpenos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Euphorbia / Diterpenos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article