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When your brain looks older than expected: combined lifestyle risk and BrainAGE.
Bittner, Nora; Jockwitz, Christiane; Franke, Katja; Gaser, Christian; Moebus, Susanne; Bayen, Ute J; Amunts, Katrin; Caspers, Svenja.
Afiliación
  • Bittner N; Institute for Anatomy I, Medical Faculty, Heinrich-Heine University Düsseldorf, Universitätstr. 1, 40225, Düsseldorf, Germany.
  • Jockwitz C; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany.
  • Franke K; Institute for Anatomy I, Medical Faculty, Heinrich-Heine University Düsseldorf, Universitätstr. 1, 40225, Düsseldorf, Germany.
  • Gaser C; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany.
  • Moebus S; Structural Brain Mapping Group, University Hospital Jena, 07743, Jena, Germany.
  • Bayen UJ; Structural Brain Mapping Group, University Hospital Jena, 07743, Jena, Germany.
  • Amunts K; Institute of Urban Public Health, University of Duisburg-Essen, 45122, Essen, Germany.
  • Caspers S; Mathematical and Cognitive Psychology, Institute for Experimental Psychology, Heinrich-Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Brain Struct Funct ; 226(3): 621-645, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33423086
ABSTRACT
Lifestyle may be one source of unexplained variance in the great interindividual variability of the brain in age-related structural differences. While physical and social activity may protect against structural decline, other lifestyle behaviors may be accelerating factors. We examined whether riskier lifestyle correlates with accelerated brain aging using the BrainAGE score in 622 older adults from the 1000BRAINS cohort. Lifestyle was measured using a combined lifestyle risk score, composed of risk (smoking, alcohol intake) and protective variables (social integration and physical activity). We estimated individual BrainAGE from T1-weighted MRI data indicating accelerated brain atrophy by higher values. Then, the effect of combined lifestyle risk and individual lifestyle variables was regressed against BrainAGE. One unit increase in combined lifestyle risk predicted 5.04 months of additional BrainAGE. This prediction was driven by smoking (0.6 additional months of BrainAGE per pack-year) and physical activity (0.55 less months in BrainAGE per metabolic equivalent). Stratification by sex revealed a stronger association between physical activity and BrainAGE in males than females. Overall, our observations may be helpful with regard to lifestyle-related tailored prevention measures that slow changes in brain structure in older adults.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Atrofia / Encéfalo / Envejecimiento / Ejercicio Físico / Estilo de Vida Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Atrofia / Encéfalo / Envejecimiento / Ejercicio Físico / Estilo de Vida Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Alemania