Automated, quantitative assessment of epidermal necrosis expression resulting from skin exposure to beta radiation.
Biomed Phys Eng Express
; 6(1): 015007, 2019 11 25.
Article
en En
| MEDLINE
| ID: mdl-33438595
ABSTRACT
PURPOSE:
Radiation skin injuries are difficult to quantitatively assess. Various scoring scales exist based on visual images and can be used in quantitative form for histological scoring. As an alternative to human scoring systems, an automated, quantitative system is proposed to provide unbiased scoring of radiation skin injury biopsy samples, with comparisons to human-based scoring systems. MATERIALS ANDMETHODS:
A unique algorithm was developed and tested on a sample pool obtained from in-vivo beta radiation experiments with a porcine model. The grading results achieved by the developed algorithm and those provided by an expert histopathologist are compared.RESULTS:
The extent of the epidermal necrosis is quantified in terms of the number of dead cells and their respective distribution across the length of the samples. The accuracy of the grading performed by the automated algorithm is comparable to that of a trained histopathologist, as demonstrated by statistically significant difference between the grades.CONCLUSIONS:
This study demonstrates the feasibility of the proposed method as a potential tool designed to aid in the histopathological analysis of the tissues affected by beta radiation exposure. An expanded study with a larger sample pool is recommended to further improve the accuracy of the proposed algorithm.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos Experimentales por Radiación
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Piel
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Partículas beta
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biomed Phys Eng Express
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos