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Antiviral Potential of Algal Metabolites-A Comprehensive Review.
Pagarete, António; Ramos, Ana Sofia; Puntervoll, Pål; Allen, Michael J; Verdelho, Vítor.
Afiliación
  • Pagarete A; Edificio TecLabs, Faculdade de Ciências, Biosystems and Integrative Sciences Institute (BioISI), Universidade de Lisboa, Campus da FCUL, Campo Grande, 1749-016 Lisboa, Portugal.
  • Ramos AS; Algae for Future, SA, Rua Eng. Clément Dumoulin Business Park, 2625-106 Póvoa de Santa Iria, Portugal.
  • Puntervoll P; Institute of Biochemistry, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
  • Allen MJ; NORCE Norwegian Research Centre, Postboks 22 Nygårdstangen, 5838 Bergen, Norway.
  • Verdelho V; Plymouth Marine Laboratory, Plymouth PL1 3DH, UK.
Mar Drugs ; 19(2)2021 Feb 06.
Article en En | MEDLINE | ID: mdl-33562153
Historically, algae have stimulated significant economic interest particularly as a source of fertilizers, feeds, foods and pharmaceutical precursors. However, there is increasing interest in exploiting algal diversity for their antiviral potential. Here, we present an overview of 50-years of scientific and technological developments in the field of algae antivirals. After bibliometric analysis of 999 scientific references, a survey of 16 clinical trials and analysis of 84 patents, it was possible to identify the dominant algae, molecules and viruses that have been shaping and driving this promising field of research. A description of the most promising discoveries is presented according to molecule class. We observed a diverse range of algae and respective molecules displaying significant antiviral effects against an equally diverse range of viruses. Some natural algae molecules, like carrageenan, cyanovirin or griffithsin, are now considered prime reference molecules for their outstanding antiviral capacity. Crucially, while many algae antiviral applications have already reached successful commercialization, the large spectrum of algae antiviral capacities already identified suggests a strong potential for future expansion of this field.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Algas Marinas / Microalgas Tipo de estudio: Prognostic_studies Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Portugal

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Algas Marinas / Microalgas Tipo de estudio: Prognostic_studies Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Portugal