Biomolecular Modeling and Simulation: A Prospering Multidisciplinary Field.
Annu Rev Biophys
; 50: 267-301, 2021 05 06.
Article
en En
| MEDLINE
| ID: mdl-33606945
ABSTRACT
We reassess progress in the field of biomolecular modeling and simulation, following up on our perspective published in 2011. By reviewing metrics for the field's productivity and providing examples of success, we underscore the productive phase of the field, whose short-term expectations were overestimated and long-term effects underestimated. Such successes include prediction of structures and mechanisms; generation of new insights into biomolecular activity; and thriving collaborations between modeling and experimentation, including experiments driven by modeling. We also discuss the impact of field exercises and web games on the field's progress. Overall, we note tremendous success by the biomolecular modeling community in utilization of computer power; improvement in force fields; and development and application of new algorithms, notably machine learning and artificial intelligence. The combined advances are enhancing the accuracy andscope of modeling and simulation, establishing an exemplary discipline where experiment and theory or simulations are full partners.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Simulación por Computador
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Annu Rev Biophys
Asunto de la revista:
BIOFISICA
Año:
2021
Tipo del documento:
Article