Covalent Organic Framework-Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy.
Bioconjug Chem
; 32(4): 661-666, 2021 04 21.
Article
en En
| MEDLINE
| ID: mdl-33710853
ABSTRACT
Sonodynamic therapy (SDT) has attracted wide attention for its high tissue-penetration depth capacity. However, developing new kinds of sonosensitizers that are capable of generating large amounts of reactive oxygen species (ROS) still remains a challenge. Herein, covalent organic framework-titanium oxide nanoparticles (COF-TiO2 NPs) were successfully synthesized by using COF as a template. Under ultrasound (US) irradiation, large quantities of ROS can be generated, and compared with pure TiO2 NPs, the SDT performance of COF-TiO2 nanoparticles was significantly improved due to the narrower band gap. Both in vitro and in vivo experiments demonstrated the great tumor inhibitory effect via COF-TiO2-mediated SDT. This work broadens the biomedical applications of COF-based composites.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Titanio
/
Terapia por Ultrasonido
/
Nanocompuestos
/
Estructuras Metalorgánicas
Límite:
Humans
Idioma:
En
Revista:
Bioconjug Chem
Asunto de la revista:
BIOQUIMICA
Año:
2021
Tipo del documento:
Article