Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus.
Annu Rev Biochem
; 90: 321-348, 2021 06 20.
Article
en En
| MEDLINE
| ID: mdl-33770447
ABSTRACT
Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus. In the 1970s, researchers showed that viral transcription depends on host RNA polymerase II (RNAP II) activity and subsequently that FluPol snatches capped oligomers from nascent RNAP II transcripts to prime its own transcription. Exactly how this occurs remains elusive. Here, we review recent advances in the mechanistic understanding of FluPol transcription and early events in RNAP II transcription that are relevant to cap-snatching. We describe the known direct interactions between FluPol and the RNAP II C-terminal domain and summarize the transcription-related host factors that have been found to interact with FluPol. We also discuss open questions regarding how FluPol may be targeted to actively transcribing RNAP II and the exact context and timing of cap-snatching, which is presumed to occur after cap completion but before the cap is sequestered by the nuclear cap-binding complex.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Orthomyxoviridae
/
Transcripción Genética
/
Proteínas Virales
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ARN Polimerasa Dependiente del ARN
/
Interacciones Huésped-Patógeno
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2021
Tipo del documento:
Article