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Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients.
Aoude, Lauren G; Wong, Bernadette Z Y; Bonazzi, Vanessa F; Brosda, Sandra; Walters, Shaun B; Koufariotis, Lambros T; Naeini, Marjan M; Pearson, John V; Oey, Harald; Patel, Kalpana; Bradford, Julia J; Bloxham, Conor J; Atkinson, Victoria; Law, Phillip; Strutton, Geoffrey; Bayley, Gerard; Yang, Samuel; Smithers, B Mark; Waddell, Nicola; Miles, Kenneth; Barbour, Andrew P.
Afiliación
  • Aoude LG; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia. l.aoude@uq.edu.au.
  • Wong BZY; Princess Alexandra Hospital, Department of Medical Imaging, Woolloongabba, Queensland, Australia.
  • Bonazzi VF; Department of Medical Imaging, Gold Coast University Hospital, Southport, Australia.
  • Brosda S; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Walters SB; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Koufariotis LT; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
  • Naeini MM; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  • Pearson JV; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  • Oey H; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
  • Patel K; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Bradford JJ; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Bloxham CJ; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Atkinson V; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  • Law P; Queensland Melanoma Project, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  • Strutton G; Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
  • Bayley G; Princess Alexandra Hospital, Department of Medical Imaging, Woolloongabba, Queensland, Australia.
  • Yang S; Department of Anatomical Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  • Smithers BM; Queensland Melanoma Project, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  • Waddell N; Queensland Melanoma Project, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  • Miles K; Queensland Melanoma Project, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  • Barbour AP; Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
Mol Cancer Res ; 19(6): 950-956, 2021 06.
Article en En | MEDLINE | ID: mdl-33811161
Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techniques are necessary for the development of predictive/prognostic biomarkers. PET/CT scans from 52 patients with stage III/IV melanoma were assessed and CT image parameters were evaluated as prognostic biomarkers. Analysis indicated patients with high standard deviation or high mean of positive pixels (MPP) had worse progression-free survival (P = 0.00047 and P = 0.0014, respectively) and worse overall survival (P = 0.0223 and P = 0.0465, respectively). Whole-exome sequencing showed high MPP was associated with BRAF mutation status (P = 0.0389). RNA-sequencing indicated patients with immune "cold" signatures had worse survival, which was associated with CT biomarker, MPP4 (P = 0.0284). Multiplex immunofluorescence confirmed a correlation between CD8 expression and image biomarkers (P = 0.0028). IMPLICATIONS: CT parameters have the potential to be cost-effective biomarkers of survival in melanoma, and reflect the tumor immune-microenvironment. VISUAL OVERVIEW: http://mcr.aacrjournals.org/content/molcanres/19/6/950/F1.large.jpg.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Linfocitos T CD8-positivos / Tomografía Computarizada por Tomografía de Emisión de Positrones / Melanoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mol Cancer Res Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Linfocitos T CD8-positivos / Tomografía Computarizada por Tomografía de Emisión de Positrones / Melanoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mol Cancer Res Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Australia