Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.

Sun, Young Joo; Velez, Gabriel; Parsons, Dylan E; Li, Kun; Ortiz, Miguel E; Sharma, Shaunik; McCray, Paul B; Bassuk, Alexander G; Mahajan, Vinit B

Sun, Young Joo; Velez, Gabriel; Parsons, Dylan E; Li, Kun; Ortiz, Miguel E; Sharma, Shaunik; McCray, Paul B; Bassuk, Alexander G; Mahajan, Vinit B.

Afiliación

Sun YJ; Molecular Surgery Lab, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, California, USA.
Velez G; Molecular Surgery Lab, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, California, USA.
Parsons DE; Medical Scientist Training Program, University of Iowa, Iowa City, Iowa, USA.
Li K; Molecular Surgery Lab, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, California, USA.
Ortiz ME; Stanford ChEM-H Medicinal Chemistry Knowledge Center, Stanford University, Palo Alto, California, USA.
Sharma S; Department of Pediatrics.
McCray PB; Department of Pediatrics.
Bassuk AG; Department of Pediatrics.
Mahajan VB; Department of Pediatrics.

J Clin Invest ; 131(10)2021 05 17.

Article en En | MEDLINE | ID: mdl-33844653

Asunto(s)

COVID-19; Filogenia; SARS-CoV-2/fisiología; Serina Endopeptidasas; Inhibidores de Serina Proteinasa; Internalización del Virus/efectos de los fármacos; Replicación Viral/efectos de los fármacos; Animales; COVID-19/enzimología; COVID-19/genética; COVID-19/prevención & control; Chlorocebus aethiops; Femenino; Células HEK293; Humanos; Masculino; Ratones; Serina Endopeptidasas/química; Serina Endopeptidasas/genética; Serina Endopeptidasas/metabolismo; Inhibidores de Serina Proteinasa/química; Inhibidores de Serina Proteinasa/farmacología; Relación Estructura-Actividad; Células Vero

Palabras clave

COVID-19; Drug screens; Infectious disease; Molecular biology; Proteases

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Filogenia / Replicación Viral / Serina Endopeptidasas / Inhibidores de Serina Proteinasa / Internalización del Virus / SARS-CoV-2 / COVID-19 Límite: Animals / Female / Humans / Male Idioma: En Revista: J Clin Invest Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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