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Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Qiu, Hui; Ali, Zahid; Bender, Andrew; Caldwell, Richard; Chen, Yi-Ying; Fang, Zhizhou; Gardberg, Anna; Glaser, Nina; Goettsche, Anja; Goutopoulos, Andreas; Grenningloh, Roland; Hanschke, Bettina; Head, Jared; Johnson, Theresa; Jones, Christopher; Jones, Reinaldo; Kulkarni, Shashank; Maurer, Christine; Morandi, Federica; Neagu, Constantin; Poetzsch, Sven; Potnick, Justin; Schmidt, Ralf; Roe, Katherine; Viacava Follis, Ariele; Wing, Carolyn; Zhu, Xiaohua; Sherer, Brian.
Afiliación
  • Qiu H; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1). Electronic address: hui.qiu@emdserono.com.
  • Ali Z; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Bender A; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Caldwell R; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Chen YY; Stoke Therapeutics, 45 Wiggins Ave, Bedford, MA 01730, USA.
  • Fang Z; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Gardberg A; Constellation Pharmaceuticals, 215 First St #200, Cambridge, MA 02142, USA.
  • Glaser N; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Goettsche A; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Goutopoulos A; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Grenningloh R; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Hanschke B; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Head J; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Johnson T; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Jones C; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Jones R; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Kulkarni S; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Maurer C; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Morandi F; Roche Pharma Research and Early Development, Grenzacherstrasse 124, Basel, Basel-Stadt, CH 4070, Switzerland.
  • Neagu C; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Poetzsch S; Merck KGaA, Frankfurter Strasse 250, Darmstadt, Hessen, DE 64293, Germany.
  • Potnick J; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Schmidt R; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Roe K; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Viacava Follis A; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Wing C; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Zhu X; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
  • Sherer B; EMD Serono Research & Development Institute, 45A Middlesex Turnpike, Billerica, MA 01821, USA(1).
Bioorg Med Chem ; 40: 116163, 2021 06 15.
Article en En | MEDLINE | ID: mdl-33932711
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Agammaglobulinemia Tirosina Quinasa / Imidazoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Agammaglobulinemia Tirosina Quinasa / Imidazoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article