Retinol-binding protein 4 and plasminogen activator inhibitor-1 as potential prognostic biomarkers of non-allergic asthma caused by obesity in adolescents.
Allergol Immunopathol (Madr)
; 49(3): 21-29, 2021.
Article
en En
| MEDLINE
| ID: mdl-33938185
ABSTRACT
BACKGROUND:
Non-allergic asthma caused by obesity is a complication of the low-grade chronic inflammation inherent in obesity. Consequently, the serum concentrations of adipokines such as retinol-binding protein 4 (RBP4) and plasminogen activator inhibitor-1 (PAI-1) increase. No gold standard molecule for the prediction of non-allergic asthma among obese patients has been identified.OBJECTIVE:
To evaluate RBP4 and PAI-1 as prognostic biomarkers of non-allergic asthma caused by obesity.METHODS:
A cross-sectional study between four groups of adolescents (1) healthy (n = 35), (2) allergic asthma without obesity (n = 28), (3) obesity without asthma (n = 33), and (4) non-allergic asthma with obesity (n = 18).RESULTS:
RBP4 was higher in the non-allergic asthma with obesity group than in the obesity without asthma group (39.2 ng/mL [95% confidence interval (CI) 23.8-76.0] vs. 23.5 ng/mL [95% CI 3.2-33.5], p < 0.01), and PAI-1 was higher in the non-allergic asthma with obesity group than in the obesity without asthma group (21.9 ng/mL [95% CI 15.7-26.5] vs. 15.9 ng/mL [95% CI 9.4-18.2], p < 0.05). Receiver operating characteristic (ROC) curve analysis demonstrated that the serum RBP4 cut-off value was >42.78 ng/mL, with an area under the ROC curve (AUC) of 0.741 (95% CI 0.599-0.853, p = 0.001), considered acceptable. The PAI-1 cut-off value was >12.0 ng/mL, with an AUC of 0.699 (95% CI 0.554-0.819, p = 0.008), considered fair.CONCLUSIONS:
RBP4 may be useful to predict non-allergic asthma among obese adolescents in clinical practice.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Inhibidor 1 de Activador Plasminogénico
/
Proteínas Plasmáticas de Unión al Retinol
/
Obesidad Infantil
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Allergol Immunopathol (Madr)
Año:
2021
Tipo del documento:
Article
País de afiliación:
México