Systemic Immunosuppression and Risk of Endophthalmitis After Intravitreal Anti-Vascular Endothelial Growth Factor Injections.
Ophthalmic Surg Lasers Imaging Retina
; 52(S1): S17-S22, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-34310237
ABSTRACT
BACKGROUND AND OBJECTIVE:
To evaluate the impact of systemic immunosuppressive therapy on the rates and outcomes of endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injections. PATIENTS ANDMETHODS:
A retrospective, single-center, comparative cohort study examining eyes undergoing intravitreal anti-VEGF injections from January 2016 to September 2019. Cohorts were created based on concurrent immunosuppressive therapy at time of injection.RESULTS:
Of 270,347 anti-VEGF injections administered, 1,300 injections (0.48%) were administered while on systemic immunosuppressive therapy. The odds of endophthalmitis occurring in the immunosuppression group was 9.86 (95% confidence interval [CI], 4.0-24.3; P < .001) times higher than the no-immunosuppression group. Symptom onset occurred 2.51 (95% CI, 0.15-4.870; P = .040) days earlier in the immunosuppression cohort; visual acuity at 6 months after treatment was similar in both groups.CONCLUSIONS:
Patients on systemic immunosuppressive medications undergoing intravitreal injections may be at increased risk for post-injection endophthalmitis and may have earlier symptom onset. However, visual outcomes were similar between the two groups. [Ophthalmic Surg Lasers Imaging Retina. 2021;52S17-S22.].
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Bacterianas del Ojo
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Endoftalmitis
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Ophthalmic Surg Lasers Imaging Retina
Año:
2021
Tipo del documento:
Article