Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

Challa, Sridevi; Khulpateea, Beman R; Nandu, Tulip; Camacho, Cristel V; Ryu, Keun W; Chen, Hao; Peng, Yan; Lea, Jayanthi S; Kraus, W Lee

Challa, Sridevi; Khulpateea, Beman R; Nandu, Tulip; Camacho, Cristel V; Ryu, Keun W; Chen, Hao; Peng, Yan; Lea, Jayanthi S; Kraus, W Lee.

Afiliación

Challa S; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Khulpateea BR; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Nandu T; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Camacho CV; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ryu KW; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chen H; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Peng Y; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lea JS; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kraus WL; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu.

Cell ; 184(17): 4531-4546.e26, 2021 08 19.

Article en En | MEDLINE | ID: mdl-34314702

Asunto(s)

ADP-Ribosilación; Neoplasias Ováricas/metabolismo; Biosíntesis de Proteínas; Proteostasis; Ribosomas/metabolismo; Regiones no Traducidas 3'/genética; Animales; Secuencia de Bases; Línea Celular Tumoral; Proliferación Celular; Estrés del Retículo Endoplásmico; Trompas Uterinas/metabolismo; Femenino; Humanos; Ratones Endogámicos NOD; Ratones SCID; NAD/metabolismo; Nicotinamida-Nucleótido Adenililtransferasa; Conformación de Ácido Nucleico; Neoplasias Ováricas/patología; Poli(ADP-Ribosa) Polimerasas/metabolismo; Polirribosomas/metabolismo; ARN Mensajero/química; ARN Mensajero/genética; ARN Mensajero/metabolismo; ARN Interferente Pequeño/metabolismo; Proteínas Ribosómicas/metabolismo

Palabras clave

ADP-ribosylation; MARylation; NAD(+); NAD(+) sensor; NAD(+) synthesis; NMNAT-2; PARP-16; cancer; mRNA translation; mono(ADP-ribose); mono(ADP-ribosyl)ation; ovarian cancer; protein aggregation; protein synthesis; ribosomes; translation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Ribosomas / Biosíntesis de Proteínas / ADP-Ribosilación / Proteostasis Límite: Animals / Female / Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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