Iridium-Triggered Allylcarbamate Uncaging in Living Cells.
Inorg Chem
; 60(17): 12644-12650, 2021 Sep 06.
Article
en En
| MEDLINE
| ID: mdl-34392682
ABSTRACT
Designing a metal catalyst that addresses the major issues of solubility, stability, toxicity, cell uptake, and reactivity within complex biological milieu for bioorthogonal controlled transformation reactions is a highly formidable challenge. Herein, we report an organoiridium complex that is nontoxic and capable of the uncaging of allyloxycarbonyl-protected amines under biologically relevant conditions and within living cells. The potential applications of this uncaging chemistry have been demonstrated by the generation of diagnostic and therapeutic agents upon the activation of profluorophore and prodrug in a controlled fashion within HeLa cells, providing a valuable tool for numerous potential biological and therapeutic applications.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carbamatos
/
Profármacos
/
Complejos de Coordinación
Límite:
Humans
Idioma:
En
Revista:
Inorg Chem
Año:
2021
Tipo del documento:
Article
País de afiliación:
India