Feasibility and Performance of Self-Collected Nasal Swabs for Detection of Influenza Virus, Respiratory Syncytial Virus, and Human Metapneumovirus.
J Infect Dis
; 224(5): 831-838, 2021 09 01.
Article
en En
| MEDLINE
| ID: mdl-34467984
ABSTRACT
BACKGROUND:
We assessed performance of participant-collected midturbinate nasal swabs compared to study staff-collected midturbinate nasal swabs for the detection of respiratory viruses among pregnant women in Bangkok, Thailand.METHODS:
We enrolled pregnant women aged ≥18 years and followed them throughout the 2018 influenza season. Women with acute respiratory illness self-collected midturbinate nasal swabs at home for influenza viruses, respiratory syncytial viruses (RSV), and human metapneumoviruses (hMPV) real-time RT-PCR testing and the study nurse collected a second midturbinate nasal swab during home visits. Paired specimens were processed and tested on the same day.RESULTS:
The majority (109, 60%) of 182 participants were 20-30 years old. All 200 paired swabs had optimal specimen quality. The median time from symptom onsets to participant-collected swabs was 2 days and to staff-collected swabs was also 2 days. The median time interval between the 2 swabs was 2 hours. Compared to staff-collected swabs, the participant-collected swabs were 93% sensitive and 99% specific for influenza virus detection, 94% sensitive and 99% specific for RSV detection, and 100% sensitive and 100% specific for hMPV detection.CONCLUSIONS:
Participant-collected midturbinate nasal swabs were a valid alternative approach for laboratory confirmation of influenza-, RSV-, and hMPV-associated illnesses among pregnant women in a community setting.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Orthomyxoviridae
/
Infecciones del Sistema Respiratorio
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Manejo de Especímenes
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Nasofaringe
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Virus Sincitial Respiratorio Humano
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Infecciones por Virus Sincitial Respiratorio
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Infecciones por Paramyxoviridae
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Metapneumovirus
/
Gripe Humana
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
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Female
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Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Infect Dis
Año:
2021
Tipo del documento:
Article
País de afiliación:
Tailandia