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The central role of Italy in the spatial spread of USUTU virus in Europe.
Zecchin, B; Fusaro, A; Milani, A; Schivo, A; Ravagnan, S; Ormelli, S; Mavian, C; Michelutti, A; Toniolo, F; Barzon, L; Monne, I; Capelli, G.
Afiliación
  • Zecchin B; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Fusaro A; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Milani A; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Schivo A; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Ravagnan S; National Reference Centre/OIE Collaborating Centre for Diseases at the Animal-Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Ormelli S; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Mavian C; Emerging Pathogens Institute, Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
  • Michelutti A; National Reference Centre/OIE Collaborating Centre for Diseases at the Animal-Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Toniolo F; National Reference Centre/OIE Collaborating Centre for Diseases at the Animal-Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Barzon L; Department of Molecular Medicine, University of Padua, Padova, Italy.
  • Monne I; Department of Research and Innovation, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Capelli G; National Reference Centre/OIE Collaborating Centre for Diseases at the Animal-Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Virus Evol ; 7(1): veab048, 2021 Jan.
Article en En | MEDLINE | ID: mdl-34513027
ABSTRACT
USUTU virus (USUV) is an arbovirus maintained in the environment through a bird-mosquito enzootic cycle. Previous surveillance plans highlighted the endemicity of USUV in North-eastern Italy. In this work, we sequenced 138 new USUV full genomes from mosquito pools (Culex pipiens) and wild birds collected in North-eastern Italy and we investigated the evolutionary processes (phylogenetic analysis, selection pressure and evolutionary time-scale analysis) and spatial spread of USUV strains circulating in the European context and in Italy, with a particular focus on North-eastern Italy. Our results confirmed the circulation of viruses belonging to four different lineages in Italy (EU1, EU2, EU3 and EU4), with the newly sequenced viruses from the North-eastern regions, Veneto and Friuli Venezia Giulia, belonging to the EU2 lineage and clustering into two different sub-lineages, EU2-A and EU2-B. Specific mutations characterize each European lineage and geographic location seem to have shaped their phylogenetic structure. By investigating the spatial spread in Europe, we were able to show that Italy acted mainly as donor of USUV to neighbouring countries. At a national level, we identified two geographical clusters mainly circulating in Northern and North-western Italy, spreading both northward and southward. Our analyses provide important information on the spatial and evolutionary dynamics of USUTU virus that can help to improve surveillance plans and control strategies for this virus of increasing concern for human health.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Virus Evol Año: 2021 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Virus Evol Año: 2021 Tipo del documento: Article País de afiliación: Italia