Repurposing Colchicine for Heart Disease.
Annu Rev Pharmacol Toxicol
; 62: 121-129, 2022 01 06.
Article
en En
| MEDLINE
| ID: mdl-34587458
Colchicine is one of the most ancient medications still prescribed. It is extracted from the Colchicum autumnale plant and is routinely used because of its broad anti-inflammatory properties to treat gout and familial Mediterranean fever. Colchicine has shown efficacy in various clinical settings in which inflammation is a key component, and it has become first-line therapy for acute and recurrent pericarditis. Two landmark clinical trials have recently shown that colchicine significantly improves cardiovascular outcomes on background statin and antiplatelet therapy in patients with coronary artery disease, supporting its role for the prevention of atherothrombotic events. Favorable results have also emerged in atrial fibrillation. We herein briefly review the most recent data related to the multiple cardiovascular conditions for which colchicine has been successfully repurposed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pericarditis
/
Fibrilación Atrial
/
Enfermedad de la Arteria Coronaria
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Pharmacol Toxicol
Año:
2022
Tipo del documento:
Article