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Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet.
Yau, Belinda; Naghiloo, Sheyda; Diaz-Vegas, Alexis; Carr, Austin V; Van Gerwen, Julian; Needham, Elise J; Jevon, Dillon; Chen, Sing-Young; Hoehn, Kyle L; Brandon, Amanda E; Macia, Laurance; Cooney, Gregory J; Shortreed, Michael R; Smith, Lloyd M; Keller, Mark P; Thorn, Peter; Larance, Mark; James, David E; Humphrey, Sean J; Kebede, Melkam A.
Afiliación
  • Yau B; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Naghiloo S; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Diaz-Vegas A; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
  • Carr AV; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Van Gerwen J; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
  • Needham EJ; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
  • Jevon D; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Chen SY; Department of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia.
  • Hoehn KL; Department of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia.
  • Brandon AE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
  • Macia L; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Cooney GJ; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Shortreed MR; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Smith LM; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Keller MP; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Thorn P; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
  • Larance M; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • James DE; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
  • Humphrey SJ; Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
  • Kebede MA; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
iScience ; 24(10): 103099, 2021 Oct 22.
Article en En | MEDLINE | ID: mdl-34622154
Pancreatic islets are essential for maintaining physiological blood glucose levels, and declining islet function is a hallmark of type 2 diabetes. We employ mass spectrometry-based proteomics to systematically analyze islets from 9 genetic or diet-induced mouse models representing a broad cross-section of metabolic health. Quantifying the islet proteome to a depth of >11,500 proteins, this study represents the most detailed analysis of mouse islet proteins to date. Our data highlight that the majority of islet proteins are expressed in all strains and diets, but more than half of the proteins vary in expression levels, principally due to genetics. Associating these varied protein expression levels on an individual animal basis with individual phenotypic measures reveals islet mitochondrial function as a major positive indicator of metabolic health regardless of strain. This compendium of strain-specific and dietary changes to mouse islet proteomes represents a comprehensive resource for basic and translational islet cell biology.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: IScience Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: IScience Año: 2021 Tipo del documento: Article País de afiliación: Australia