Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection.
Physiology (Bethesda)
; 37(2): 88-100, 2022 03 01.
Article
en En
| MEDLINE
| ID: mdl-34698589
ABSTRACT
The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here, we outline the multistep mechanisms of lung epithelial and endothelial injury induced by SARS-CoV-2 direct viral infection, chemokine/cytokine-mediated damage, and immune cell-mediated lung injury. Finally, we discuss the recent progress in terms of antiviral therapeutics as well as the development of anti-inflammatory or immunomodulatory therapeutic approaches. This review also provides a systematic overview of the models for studying SARS-CoV-2 infection and discusses how an understanding of mechanisms of lung injury will help identify potential targets for future drug development to mitigate lung injury.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lesión Pulmonar
/
COVID-19
Límite:
Humans
Idioma:
En
Revista:
Physiology (Bethesda)
Asunto de la revista:
FISIOLOGIA
Año:
2022
Tipo del documento:
Article