Histo-Blood Group Antigens, Enteropathogen Carriage and Environmental Enteropathy in Stunted Zambian Children.
J Pediatr Gastroenterol Nutr
; 74(4): 529-534, 2022 04 01.
Article
en En
| MEDLINE
| ID: mdl-34724448
ABSTRACT
OBJECTIVES:
Stunting, the most common form of childhood undernutrition, is associated with environmental enteropathy (EE). Enteric infections are believed to play a role in the pathophysiology of EE and stunting though the exact mechanism remains undetermined. The FUT2 (secretor) and FUT3 (Lewis) genes have been shown to be associated with some symptomatic enteric infections in both children and adults. These genes are responsible for the presence of histo-blood group antigens (HBGAs) in various secretions and epithelial surfaces.We evaluated whether the secretor and Lewis status influences asymptomatic enteric infections and thus EE severity on duodenal biopsies of stunted children.METHODS:
In this case-control study, we used saliva samples to determine the secretor and Lewis status of stunted children (cases, nâ=â113) enrolled in a nutritional rehabilitation program and from their well-nourished counterparts (controls, nâ=â42). Where available, saliva was also collected from the mothers. Baseline stool samples were used to detect asymptomatic enteropathogen carriage. Duodenal biopsies were collected from a subgroup of stunted children (nâ=â77) who had an upper gastrointestinal endoscopy done as part of the evaluation process for their non-response to nutritional therapy.RESULTS:
The proportion of secretors was similar between the cases and the controls (82% vs 81%, Pâ=â0.81). The stunted children had significantly higher rates of carrying multiple enteropathogens, but this was not associated with their secretor status nor that of their mothers. The secretor status was also not associated with mucosal morphometry of duodenal biopsies.CONCLUSION:
This case-control analysis in Zambian children does not support the hypothesis that fucosylation status determines asymptomatic enteropathogen carriage in stunting.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antígenos de Grupos Sanguíneos
/
Enfermedades Intestinales
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Female
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2022
Tipo del documento:
Article