Life support for transitory exhausted CTLs.

Mohamed, Asmaa; Huang, Yina H

Mohamed, Asmaa; Huang, Yina H.

Afiliación

Mohamed A; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Huang YH; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Norris Cotton Cancer Center, Lebanon, NH, USA; Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Electronic address: yina@dartmouth.edu.

Trends Immunol ; 42(12): 1057-1059, 2021 12.

Article en En | MEDLINE | ID: mdl-34772619

RESUMEN

Di Pilato et al. demonstrate that CXCR6 positions TCF-1- transitory CD8+ cytotoxic lymphocytes (CTLs) with perivascular CCR7+ dendritic cells (DCs) within the tumor stroma to receive IL-15 survival signals. The requirement for CXCR6 and its strong prediction of overall patient survival highlight the importance of continued CTL-DC interactions in sustaining tumor immunity.

Asunto(s)

Neoplasias; Linfocitos T Citotóxicos; Linfocitos T CD8-positivos; Células Dendríticas; Humanos; Neoplasias/terapia; Transducción de Señal

Palabras clave

CXCR6CXCL16; DC3; IL-15 trans-presentation; perivascular niche; transitory effector T cell; tumor immunity

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Neoplasias Límite: Humans Idioma: En Revista: Trends Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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