Outcomes of Continuous Renal Replacement Therapy in a Community Health System.
J Intensive Care Med
; 37(8): 1043-1048, 2022 Aug.
Article
en En
| MEDLINE
| ID: mdl-34812078
ABSTRACT
OBJECTIVE:
Continuous renal replacement therapy (CRRT) is commonly used in critically ill, hemodynamically unstable patients with acute kidney injury (AKI). This procedure is resource intensive with reported high in-hospital mortality. We evaluated mortality with CRRT in our healthcare system and markers associated with decreased survival.METHODS:
A retrospective cohort study collected data on patients 18 years or older, without prior history of end stage kidney disease (ESKD), who received CRRT in the intensive care units at one of three hospitals in our health system in Columbus, OH from July 1, 2016 to July 1, 2019. Data included demographics, presenting diagnosis, comorbidities, laboratory markers, and patient disposition. In-hospital mortality rates and sequential organ failure assessment (SOFA) scores were calculated. We then compared information between two groups (patients who died during hospitalization and survivors) using univariate comparisons and multivariate logistic regression models.RESULTS:
In-hospital mortality was 56.8% (95%CI 53.4-60.1) among patients who received CRRT. Mean SOFA scores did not differ between survival and mortality groups. The odds for in-patient mortality were increased for patients age ≥60 (OR = 1.74, 95%CI 1.23-2.44), first bilirubin >2â mg/dL (OR = 1.73, 95%CI 1.12-2.69), first creatinine < 2â mg/dL (OR = 1.57, 95%CI 1.04-2.37), first lactate > 2â mmol/L (OR = 2.08, 95%CI 1.43-3.04). The odds for in-patient mortality were decreased for patients with cardiogenic shock (OR = .32, 95%CI .17-.58) and hemorrhagic shock (OR = .29, 95%CI .13-.63).CONCLUSIONS:
We report in-hospital mortality rates of 56.8% with CRRT. Unlike prior studies, higher mean SOFA scores were not predictive of higher in-hospital mortality in patients utilizing CRRT.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lesión Renal Aguda
/
Terapia de Reemplazo Renal Continuo
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Intensive Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos