Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes.

Hsieh, Wen-Chuan; Sutter, Benjamin M; Ruess, Holly; Barnes, Spencer D; Malladi, Venkat S; Tu, Benjamin P

Hsieh, Wen-Chuan; Sutter, Benjamin M; Ruess, Holly; Barnes, Spencer D; Malladi, Venkat S; Tu, Benjamin P.

Afiliación

Hsieh WC; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sutter BM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ruess H; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Barnes SD; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Malladi VS; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tu BP; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: benjamin.tu@utsouthwestern.edu.

Mol Cell ; 82(1): 60-74.e5, 2022 01 06.

Article en En | MEDLINE | ID: mdl-34995509

Asunto(s)

Gluconeogénesis; Glucosa/deficiencia; Histonas/metabolismo; Metabolismo de los Lípidos; Procesamiento Proteico-Postraduccional; Saccharomyces cerevisiae/metabolismo; Acetilcoenzima A/metabolismo; Acetilación; Regulación Fúngica de la Expresión Génica; Histona Acetiltransferasas/genética; Histona Acetiltransferasas/metabolismo; Histona Desacetilasas/genética; Histona Desacetilasas/metabolismo; Metabolismo de los Lípidos/genética; Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; Transactivadores/genética; Transactivadores/metabolismo

Palabras clave

Gcn5p; Rpd3p; SAGA; acetyl-CoA; environmental stress response; fat metabolism; gluconeogenesis; glucose starvation; histone acetylation; transcription

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Histonas / Procesamiento Proteico-Postraduccional / Metabolismo de los Lípidos / Gluconeogénesis / Glucosa Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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