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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.
Domenighetti, Cloé; Sugier, Pierre-Emmanuel; Ashok Kumar Sreelatha, Ashwin; Schulte, Claudia; Grover, Sandeep; Mohamed, Océane; Portugal, Berta; May, Patrick; Bobbili, Dheeraj R; Radivojkov-Blagojevic, Milena; Lichtner, Peter; Singleton, Andrew B; Hernandez, Dena G; Edsall, Connor; Mellick, George D; Zimprich, Alexander; Pirker, Walter; Rogaeva, Ekaterina; Lang, Anthony E; Koks, Sulev; Taba, Pille; Lesage, Suzanne; Brice, Alexis; Corvol, Jean-Christophe; Chartier-Harlin, Marie-Christine; Mutez, Eugénie; Brockmann, Kathrin; Deutschländer, Angela B; Hadjigeorgiou, Georges M; Dardiotis, Efthimos; Stefanis, Leonidas; Simitsi, Athina Maria; Valente, Enza Maria; Petrucci, Simona; Duga, Stefano; Straniero, Letizia; Zecchinelli, Anna; Pezzoli, Gianni; Brighina, Laura; Ferrarese, Carlo; Annesi, Grazia; Quattrone, Andrea; Gagliardi, Monica; Matsuo, Hirotaka; Kawamura, Yusuke; Hattori, Nobutaka; Nishioka, Kenya; Chung, Sun Ju; Kim, Yun Joong; Kolber, Pierre.
Afiliación
  • Domenighetti C; UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France.
  • Sugier PE; UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France.
  • Ashok Kumar Sreelatha A; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tubingen, Germany.
  • Schulte C; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany.
  • Grover S; German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany.
  • Mohamed O; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tubingen, Germany.
  • Portugal B; UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France.
  • May P; UVSQ, Univ. Paris-Sud, Inserm, Team "Exposome, Heredity, Cancer and Health," CESP, Université Paris-Saclay, Villejuif, France.
  • Bobbili DR; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-Belval, Luxembourg.
  • Radivojkov-Blagojevic M; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-Belval, Luxembourg.
  • Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
  • Singleton AB; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
  • Hernandez DG; Molecular Genetics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA.
  • Edsall C; Center For Alzheimer's and Related Dementias, NIA, NIH, Bethesda, Maryland, USA.
  • Mellick GD; Molecular Genetics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA.
  • Zimprich A; Molecular Genetics Section, Laboratory of Neurogenetics, NIA, NIH, Bethesda, Maryland, USA.
  • Pirker W; Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.
  • Rogaeva E; Department of Neurology, Medical University of Vienna, Wien, Austria.
  • Lang AE; Department of Neurology, Wilhelminenspital, Wien, Austria.
  • Koks S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Taba P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Lesage S; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Brice A; Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Corvol JC; Krembil Brain Institute, Toronto, Ontario, Canada.
  • Chartier-Harlin MC; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, Australia.
  • Mutez E; Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia.
  • Brockmann K; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
  • Deutschländer AB; Neurology Clinic, Tartu University Hospital, Tartu, Estonia.
  • Hadjigeorgiou GM; Department of Neurologie, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Dardiotis E; Department of Neurologie, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Stefanis L; Department of Neurologie, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Simitsi AM; Department of Neurology, CIC Neurosciences, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Valente EM; University Lille, Inserm, CHU Lille, UMR-S 1172-LilNCog-Centre de Recherche Lille Neurosciences & Cognition, Lille, France.
  • Petrucci S; University Lille, Inserm, CHU Lille, UMR-S 1172-LilNCog-Centre de Recherche Lille Neurosciences & Cognition, Lille, France.
  • Duga S; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany.
  • Straniero L; German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany.
  • Zecchinelli A; Department of Neurology, Ludwig Maximilians University of Munich, München, Germany.
  • Pezzoli G; Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany.
  • Brighina L; Department of Neurology and Department of Clinical Genomics, Mayo Clinic Florida, Jacksonville, Florida, USA.
  • Ferrarese C; Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
  • Annesi G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
  • Quattrone A; Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
  • Gagliardi M; First Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Matsuo H; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  • Kawamura Y; First Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Hattori N; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
  • Nishioka K; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Mondino Foundation, Pavia, Italy.
  • Chung SJ; UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy.
  • Kim YJ; Department of Clinical and Molecular Medicine, University of Rome, Rome, Italy.
  • Kolber P; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Mov Disord ; 37(4): 857-864, 2022 04.
Article en En | MEDLINE | ID: mdl-34997937
ABSTRACT

BACKGROUND:

Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

OBJECTIVE:

The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

METHODS:

We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

RESULTS:

Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).

CONCLUSIONS:

Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia