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Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.
Wang, Yuexia; Shilagardi, Khurts; Hsu, Trunee; Odinammadu, Kamsi O; Maruyama, Takamitsu; Wu, Wei; Lin, Chyuan-Sheng; Damoci, Christopher B; Spear, Eric D; Shin, Ji-Yeon; Hsu, Wei; Michaelis, Susan; Worman, Howard J.
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  • Wang Y; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Shilagardi K; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Hsu T; Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Odinammadu KO; Department of Biology, Case Western Reserve University, Cleveland, OH 44106.
  • Maruyama T; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642.
  • Wu W; Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
  • Lin CS; Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642.
  • Damoci CB; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Spear ED; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Shin JY; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Hsu W; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032.
  • Michaelis S; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032.
  • Worman HJ; Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Proc Natl Acad Sci U S A ; 119(9)2022 03 01.
Article en En | MEDLINE | ID: mdl-35197292
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Progeria / Metaloendopeptidasas / Lamina Tipo A / Longevidad / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Progeria / Metaloendopeptidasas / Lamina Tipo A / Longevidad / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article