A novel cardiovascular systems model to quantify drugs effects on the inter-relationship between contractility and other hemodynamic variables.

Fu, Yu; Taghvafard, Hadi; Said, Medhat M; Rossman, Eric I; Collins, Teresa A; Billiald-Desquand, Stéphanie; Leishman, Derek; van der Graaf, Piet H; van Hasselt, J G Coen; Snelder, Nelleke

Fu, Yu; Taghvafard, Hadi; Said, Medhat M; Rossman, Eric I; Collins, Teresa A; Billiald-Desquand, Stéphanie; Leishman, Derek; van der Graaf, Piet H; van Hasselt, J G Coen; Snelder, Nelleke.

Afiliación

Fu Y; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Taghvafard H; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Said MM; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Rossman EI; GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Collins TA; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Royston, UK.
Billiald-Desquand S; Servier, Suresnes, France.
Leishman D; Elly Lilly and Company, Indianapolis, Indiana, USA.
van der Graaf PH; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
van Hasselt JGC; Certara QSP, Canterbury, UK.
Snelder N; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

CPT Pharmacometrics Syst Pharmacol ; 11(5): 640-652, 2022 05.

Article en En | MEDLINE | ID: mdl-35213797

Asunto(s)

Sistema Cardiovascular; Contracción Miocárdica; Animales; Atenolol/farmacología; Perros; Frecuencia Cardíaca; Hemodinámica/fisiología; Humanos; Contracción Miocárdica/fisiología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Cardiovascular / Contracción Miocárdica Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

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