Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism.
RSC Med Chem
; 13(1): 79-89, 2022 Jan 27.
Article
en En
| MEDLINE
| ID: mdl-35224498
ABSTRACT
Inhibition of bacterial cell division is a novel mechanistic action in the development of new antimicrobial agents. The FtsZ protein is an important antimicrobial drug target because of its essential role in bacterial cell division. In the present study, potential inhibitors of FtsZ were identified by virtual screening followed by in vivo and in vitro bioassays. One of the candidates, Dacomitinib (S2727), shows for the first time its potent inhibitory activity against the MRSA strains. The binding mode of Dacomitinib in FtsZ was analyzed by docking, and Asp199 and Thr265 are thought to be essential residues involved in the interactions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
RSC Med Chem
Año:
2022
Tipo del documento:
Article