Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases.

Aublette, Marine C; Harrison, Tom A; Thorpe, Elizabeth J; Gadd, Morgan S

Aublette, Marine C; Harrison, Tom A; Thorpe, Elizabeth J; Gadd, Morgan S.

Afiliación

Aublette MC; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Harrison TA; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Thorpe EJ; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Gadd MS; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom. Electronic address: m.gadd@lancaster.ac.uk.

Bioorg Med Chem Lett ; 64: 128636, 2022 05 15.

Article en En | MEDLINE | ID: mdl-35231578

Asunto(s)

Proteolisis; Ubiquitina-Proteína Ligasas; Ligandos; Ubiquitina-Proteína Ligasas/metabolismo; Proteínas Tirosina Quinasas; Proteínas de Ciclo Celular; Reparación del ADN; Daño del ADN

Palabras clave

CDK1; Cereblon; Checkpoint inhibition; PROTAC; Targeted degradation; VHL; Wee1

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ubiquitina-Proteína Ligasas / Proteolisis Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

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