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[The efficacy and safety of Erenumab in patients with high-frequency episodic migraine according to the first Russian real-life study of the Research Center of Neurology]. / Effektivnost' i bezopasnost' erenumaba u patsientov s chastoi epizodicheskoi migren'yu po dannym rossiiskogo issledovaniya real'noi klinicheskoi praktiki Nauchnogo tsentra nevrologii.
Dobrynina, L A; Gubanova, M V; Belopasova, A V; Baydina, E V; Afanasev, M A.
Afiliación
  • Dobrynina LA; Research Center of Neurology, Moscow, Russia.
  • Gubanova MV; Research Center of Neurology, Moscow, Russia.
  • Belopasova AV; Research Center of Neurology, Moscow, Russia.
  • Baydina EV; Research Center of Neurology, Moscow, Russia.
  • Afanasev MA; Research Center of Neurology, Moscow, Russia.
Article en Ru | MEDLINE | ID: mdl-35271240
ABSTRACT

OBJECTIVE:

To assess the effectiveness and safety of Erenumab, a monoclonal antibody to calcitonin gene-related peptide receptors, in patients with high-frequency episodic migraine (HFEM) in real-life study. MATERIAL AND

METHODS:

35 patients with HFEM without aura (≥8-14 attacks per month) (30 females, mean age 32.4±8.1) received monthly subcutaneous administration of Erenumab 70 mg for 3 months. The primary endpoint was the change in monthly migraine days (MMDs) from baseline, the secondary endpoint was the proportion of patients who achieved a 50% reduction in the number of days with headache. The change in pain intensity, change in the number of days of use of acute migraine-specific medication, the effect on daily activity (HIT-6 scale, MIDAS), anxiety and depression (the Hospital Anxiety and Depression Scale) were assessed.

RESULTS:

At the end of the third month Erenumab decreased MMDs by 5±3.6 (p=0.00000). A 50% reduction in the mean number of migraine days per month was achieved for 60% of patients, the intensity of headache according to the visual analogue scale from 8±1.2 points to 5±2 points (p=0.00000), monthly analgesics intake passed from 11±7 to 4.5±3.7 (p=0.000001). 25.7% of patients did not respond to treatment, showing less than a 30% decrease in the number of days with headache. A decrease in pain intensity correlated with a decrease in anxiety (from 8±4 to 6±4 points (p=0.003)) and depression (from 6±4 to 4±3 points (p=0.0004)) according to HADS, reduced HIT-6 scale from 65±6 to 55±7 points (p=0.00000) and MIDAS from 45 [33; 67] points to 16 [5; 33] (p=0.000004)). Patients reported good tolerability of Erenumab. 25.7% of patients noted a tendency to constipation. No patient discontinued treatment due to adverse events.

CONCLUSION:

Real-life study confirmed the efficacy and safety of Erenumab in the treatment of HFEM, a decrease in the severity of comorbid anxiety and depression, and social maladjustment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / Antagonistas del Receptor Peptídico Relacionado con el Gen de la Calcitonina / Trastornos Migrañosos Límite: Adult / Female / Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Rusia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / Antagonistas del Receptor Peptídico Relacionado con el Gen de la Calcitonina / Trastornos Migrañosos Límite: Adult / Female / Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Rusia