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Novel approaches to increase synaptic resilience as potential treatments for Alzheimer's disease.
Pham, Andrew Q; Dore, Kim.
Afiliación
  • Pham AQ; Department of Neurosciences, Center for Neural Circuits and Behavior, UCSD, La Jolla 92093, United States.
  • Dore K; Department of Neurosciences, Center for Neural Circuits and Behavior, UCSD, La Jolla 92093, United States. Electronic address: kdore@health.ucsd.edu.
Semin Cell Dev Biol ; 139: 84-92, 2023 04.
Article en En | MEDLINE | ID: mdl-35370089
A significant proportion of brains with Alzheimer's disease pathology are obtained from patients that were cognitively normal, suggesting that differences within the brains of these individuals made them resilient to the disease. Here, we describe recent approaches that specifically increase synaptic resilience, as loss of synapses is considered to be the first change in the brains of Alzheimer's patients. We start by discussing studies showing benefit from increased expression of neurotrophic factors and protective genes. Methods that effectively make dendritic spines stronger, specifically by acting through actin network proteins, scaffolding proteins and inhibition of phosphatases are described next. Importantly, the therapeutic strategies presented in this review tackle Alzheimer's disease not by targeting plaques and tangles, but instead by making synapses resilient to the pathology associated with Alzheimer's disease, which has tremendous potential.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos