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Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial agents.
Annunziata, Francesca; Contente, Martina L; Anzi, Valentina; Donzella, Silvia; Conti, Paola; Molinari, Francesco; Martino, Piera Anna; Meroni, Gabriele; Sora, Valerio Massimo; Tamborini, Lucia; Pinto, Andrea.
Afiliación
  • Annunziata F; Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.
  • Contente ML; Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.
  • Anzi V; Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.
  • Donzella S; Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.
  • Conti P; Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.
  • Molinari F; Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.
  • Martino PA; Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.
  • Meroni G; Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.
  • Sora VM; Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.
  • Tamborini L; Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy. Electronic address: lucia.tamborini@unimi.it.
  • Pinto A; Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.
Food Chem ; 390: 133195, 2022 Oct 01.
Article en En | MEDLINE | ID: mdl-35594770
A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435®) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antimicrobial activity against four selected bacterial strains together with their efficiency as radical scavengers were evaluated. The obtained compounds were characterized by enhanced lipophilicity in comparison with the parent non-esterified compounds, which increased the possibility of their use as additives in the food industry.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ésteres / Antiinfecciosos Idioma: En Revista: Food Chem Año: 2022 Tipo del documento: Article País de afiliación: Italia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ésteres / Antiinfecciosos Idioma: En Revista: Food Chem Año: 2022 Tipo del documento: Article País de afiliación: Italia