Association of vitamin D receptor polymorphisms with vitamin D and calcium levels in Turkish multiple sclerosis patients.

Vitamin D deficiency stands out as an important environmental factor in multiple sclerosis (MS). In recent years, the role of genetic factors associated with vitamin D has also been examined. In addition to the effects of smoking habit, exposure to ultraviolet rays, latitude and inflammatory diseases on MS risk, high vitamin D levels are thought to be protective. Therefore, investigation of genetic factors that play a role in vitamin D metabolism will be helpful in elucidating the etiology of MS disease and in the development of treatment options.