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Upregulation of VSIG4 in Type 2 Diabetic Kidney Disease.
Han, Sang Youb; Ghee, Jung Yeon; Cha, Jin Joo; Kang, Young Sun; Hur, Dae Young; Kim, Han Seong; Cha, Dae Ryong.
Afiliación
  • Han SY; Department of Internal Medicine, Inje University, Ilsan-Paik Hospital, Goyang 10380, Korea.
  • Ghee JY; Department of Internal Medicine, Korea University, Ansan Hospital, Ansan 15355, Korea.
  • Cha JJ; Department of Internal Medicine, Korea University, Ansan Hospital, Ansan 15355, Korea.
  • Kang YS; Department of Internal Medicine, Korea University, Ansan Hospital, Ansan 15355, Korea.
  • Hur DY; Department of Anatomy and Tumor Immunology, Inje University College of Medicine, Busan 47392, Korea.
  • Kim HS; Department of Pathology, Inje University, Ilsan-Paik Hospital, Goyang 10380, Korea.
  • Cha DR; Department of Internal Medicine, Korea University, Ansan Hospital, Ansan 15355, Korea.
Life (Basel) ; 12(7)2022 Jul 11.
Article en En | MEDLINE | ID: mdl-35888119
ABSTRACT
Fibrosis is the final common finding in patients with advanced diabetic kidney disease. V-set Ig domain containing 4 (VSIG4) is related to fibrosis in several diseases. It also contributes to fibrosis under high-glucose conditions in renal tubule cells. To determine the role of VSIG4 in type 2 diabetes, we examined VSIG4 expression in a type 2 diabetic animal model and podocyte. Urinary excretion of albumin and VSIG4 was significantly higher in db/db mice than in the control group. Urine VSIGs levels for 6 h were about three-fold higher in db/db mice than in db/m mice at 20 weeks of age 55.2 ± 37.8 vs. 153.1 ± 74.3 ng, p = 0.04. Furthermore, urinary VSIG4 levels were significantly correlated with urinary albumin levels (r = 0.77, p < 0.01). Intrarenal VSIG4 mRNA expression was significantly higher in db/db mice than in control mice (1.00 ± 0.35 vs. 1.69 ± 0.77, p = 0.04). Further, VSIG4 expression was almost twice as high in db/db mice at 20 weeks of age. Intrarenal VSIG immunoreactivity in db/db mice was also significantly higher than that in control mice. In cultured podocytes, both high glucose and angiotensin II significantly upregulated the expression of VSIG4 mRNA and protein. In conclusion, VSIG4 was upregulated in an animal model of type 2 diabetes and was related to albuminuria and pro-fibrotic markers. Considering these relationships, VSIG4 may be an important mediator of diabetic nephropathy progression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Life (Basel) Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Life (Basel) Año: 2022 Tipo del documento: Article