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Patient-Reported Outcome Measures for Patients Who Have Clinical T4 Breast Cancer Treated via Mastectomy with and Without Reconstruction.
Palmquist, Emily; Limberg, Jessica; Chu, Jacqueline J; White, Charlie; Baser, Raymond E; Sevilimedu, Varadan; Pawloski, Kate R; Garcia, Paula; Nelson, Jonas A; Moo, Tracy-Ann; Morrow, Monica; Tadros, Audree B.
Afiliación
  • Palmquist E; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Limberg J; Department of Surgery, Weill Cornell Medicine and New York-Presbyterian, New York, NY, USA.
  • Chu JJ; Plastic and Reconstructive Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • White C; Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Baser RE; Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sevilimedu V; Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Pawloski KR; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Garcia P; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Nelson JA; Plastic and Reconstructive Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Moo TA; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Morrow M; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Tadros AB; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. tadrosa@mskcc.org.
Ann Surg Oncol ; 30(1): 115-121, 2023 Jan.
Article en En | MEDLINE | ID: mdl-36149609
ABSTRACT

BACKGROUND:

Patients with clinical T4M0 breast cancer are recommended to undergo neoadjuvant chemotherapy, modified radical mastectomy, and postmastectomy radiotherapy. This study determined whether BREAST-Q scores differ by decision to pursue reconstruction or timing of reconstruction.

METHODS:

This retrospective, single-institutional study analyzed cT4 breast cancer patients from 2014 to 2021 without evidence of distant metastatic disease undergoing mastectomy with or without reconstruction. As routine care, BREAST-Q was administered preoperatively, then 6 months, 1 year, and 2 years postoperatively. Satisfaction and quality-of-life domains were compared between mastectomy with no reconstruction (NR), immediate reconstruction (IR), and delayed reconstruction (DR) groups.

RESULTS:

Of the 144 patients eligible for this study, 71 (49%) had NR, 36 (25%) had DR, and 37 (26%) had IR. The patients undergoing reconstruction were younger and more likely to elect contralateral prophylactic mastectomy. Timing of reconstruction was not associated with significant differences in satisfaction with breasts (SATBR) at any time point. For the patients who had DR, breast satisfaction increased over time after reconstructive surgery. Physical well-being of the chest (PWB-CHEST) did not significantly differ among IR, DR, and NR at any time point. The patients who underwent DR experienced improvement in PWB-CHEST scores from preoperative scores. The patients with IR and NR experienced PWB-CHEST decline over time. Psychosocial well-being (PSWB) did not differ significantly across time or by subgroup.

CONCLUSIONS:

The patients with T4 breast cancer who elected reconstruction did not differ in patient-reported outcomes based on timing of reconstruction. In the DR cohort, SATBR significantly improved after reconstructive surgery. These data can help inform breast reconstructive decision-making for patients facing the choice among DR, IR, and NR.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos