ERK1/2 in immune signalling.
Biochem Soc Trans
; 50(5): 1341-1352, 2022 10 31.
Article
en En
| MEDLINE
| ID: mdl-36281999
ABSTRACT
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate. More recently, studies have shown that ERK1/2 plays an essential role downstream of immune receptors to elicit inflammatory gene expression in response to infection and cell or tissue damage. Much of this work has studied ERK1/2 activation in Toll-like receptor (TLR) pathways, providing mechanistic insights into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging research uncovering evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema de Señalización de MAP Quinasas
/
Quinasas MAP Reguladas por Señal Extracelular
Límite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2022
Tipo del documento:
Article
País de afiliación:
Australia