YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression.

Meng, H; Fu, S; Ferreira, M B; Hou, Y; Pearce, O M; Gavara, N; Knight, M M

Meng, H; Fu, S; Ferreira, M B; Hou, Y; Pearce, O M; Gavara, N; Knight, M M.

Afiliación

Meng H; School of Engineering and Materials Science, Queen Mary University of London, London, UK. Electronic address: Huan.meng@qmul.ac.uk.
Fu S; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ferreira MB; School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Hou Y; School of Engineering and Materials Science, Queen Mary University of London, London, UK; Centre for Predictive in Vitro Models, Queen Mary University of London, London, UK.
Pearce OM; Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Gavara N; Serra-Hunter Program, Biophysics and Bioengineering Unit, Department of Biomedicine, Medical School, University of Barcelona, Barcelona, Spain.
Knight MM; School of Engineering and Materials Science, Queen Mary University of London, London, UK; Centre for Predictive in Vitro Models, Queen Mary University of London, London, UK.

Osteoarthritis Cartilage ; 31(5): 600-612, 2023 05.

Article en En | MEDLINE | ID: mdl-36368426

Asunto(s)

Cartílago Articular; Osteoartritis; Humanos; Cartílago Articular/metabolismo; Células Cultivadas; Condrocitos/metabolismo; Cilios/metabolismo; Osteoartritis/metabolismo; ARN Interferente Pequeño/metabolismo; Transducción de Señal/fisiología; Proteínas Señalizadoras YAP/metabolismo

Palabras clave

Extracellular matrix stiffness; Inflammatory response; Matrix degradation; Primary cilia; Yes-associated protein (YAP)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartritis / Cartílago Articular Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Osteoarthritis Cartilage Asunto de la revista: ORTOPEDIA / REUMATOLOGIA Año: 2023 Tipo del documento: Article

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