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Zhongguo Dang Dai Er Ke Za Zhi
; 24(11): 1231-1237, 2022 Nov 15.
Article
en Zh
| MEDLINE
| ID: mdl-36398549
ABSTRACT
OBJECTIVES:
To summarize the skeletal muscle magnetic resonance imaging (MRI) features of the lower limbs in common subtypes of muscular dystrophy (MD) and the experience in the application of MRI in the diagnosis of MD.METHODS:
A total of 48 children with MD who were diagnosed by genetic testing were enrolled as subjects. The muscle MRI features of the lower limbs were analyzed. Cumulative fatty infiltration score was calculated for each subtype, and the correlation of cumulative fatty infiltration score with clinical indices was analyzed for Duchenne muscular dystrophy (DMD).RESULTS:
DMD was characterized by the involvement of the gluteus maximus and the adductor magnus. Becker muscular dystrophy was characterized by the involvement of the vastus lateralis muscle. Limb-girdle muscular dystrophy was characterized by the involvement of the adductor magnus, the vastus intermedius, the vastus medialis, and the vastus lateralis muscle. For DMD, the cumulative fatty infiltration score of the lower limb muscles was significantly correlated with age, course of the disease, muscle strength, and motor function (P<0.05), while it was not significantly correlated with the serum creatine kinase level (P>0.05).CONCLUSIONS:
Different subtypes of MD have different MRI manifestations, and MRI may help with the diagnosis and assessment of MD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Distrofia Muscular de Duchenne
/
Distrofia Muscular de Cinturas
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2022
Tipo del documento:
Article
País de afiliación:
China