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A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Rottner, Antje K; Ye, Yingying; Navarro-Guerrero, Elena; Rajesh, Varsha; Pollner, Alina; Bevacqua, Romina J; Yang, Jing; Spigelman, Aliya F; Baronio, Roberta; Bautista, Austin; Thomsen, Soren K; Lyon, James; Nawaz, Sameena; Smith, Nancy; Wesolowska-Andersen, Agata; Fox, Jocelyn E Manning; Sun, Han; Kim, Seung K; Ebner, Daniel; MacDonald, Patrick E; Gloyn, Anna L.
Afiliación
  • Rottner AK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Ye Y; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Navarro-Guerrero E; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Rajesh V; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Pollner A; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Bevacqua RJ; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Yang J; Stanford Diabetes Research Centre, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Spigelman AF; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Baronio R; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Bautista A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Thomsen SK; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Lyon J; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Nawaz S; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Smith N; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Wesolowska-Andersen A; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Fox JEM; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
  • Sun H; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Kim SK; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Ebner D; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • MacDonald PE; Stanford Diabetes Research Centre, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • Gloyn AL; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Nat Genet ; 55(1): 54-65, 2023 01.
Article en En | MEDLINE | ID: mdl-36543916

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido