Association between LIN28B gene polymorphisms and Wilms' tumor susceptibility.

ABSTRACT

Aim: To survey the association between LIN28B gene polymorphisms and the increased risk of Wilms' tumor (WT). Methods: Five LIN28B polymorphisms (rs314276 C>A, rs221634 A>T, rs221635 T>C, the rs4145418 A>C and rs9404590 T>G) were genotyped in 355 WT patients and 1070 healthy controls to assess the association. Result: The rs314276 CA/AA genotype was a protective factor against WT (corrected odds ratio [OR] 0.71; p = 0.006). Individuals older than 18 months (corrected OR 0.60; p = 0.001), males (corrected OR 0.65; p = 0.011) and in clinical stage I + II patients (corrected OR 0.60; p = 0.0008) with this genotype were less susceptible to WT. Conclusion: The rs314276 CA/AA genotype may protect against WT.