PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage.

Kim, Chiho; Wang, Xu-Dong; Jang, Seoyeon; Yu, Yonghao

Kim, Chiho; Wang, Xu-Dong; Jang, Seoyeon; Yu, Yonghao.

Afiliación

Kim C; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Wang XD; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Jang S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Yu Y; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. Electronic address: yy3213@cumc.columbia.edu.

Biochem Biophys Res Commun ; 646: 78-85, 2023 02 26.

Article en En | MEDLINE | ID: mdl-36706709

Asunto(s)

Neoplasias; Piroptosis; Humanos; Gasderminas; Caspasa 3/metabolismo; Poli(ADP-Ribosa) Polimerasa-1/metabolismo; Muerte Celular; Neoplasias/patología

Palabras clave

BRCA gene; Caspase 3; Gasdermin E (GSDME); PARP1 inhibitors (PARPi); Poly-ADP-Ribose-polymerase 1 (PARP1); Pyroptosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piroptosis / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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