Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors.

Jing, Chang-Bin; Prutsch, Nicole; He, Shuning; Zimmerman, Mark W; Landesman, Yosef; Look, A Thomas

Jing, Chang-Bin; Prutsch, Nicole; He, Shuning; Zimmerman, Mark W; Landesman, Yosef; Look, A Thomas.

Afiliación

Jing CB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Prutsch N; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
He S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Zimmerman MW; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Landesman Y; Karyopharm Therapeutics, Newton, Massachusetts, USA.
Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

Br J Haematol ; 201(3): 489-501, 2023 05.

Article en En | MEDLINE | ID: mdl-36746437

Asunto(s)

Dioxigenasas; Leucemia Mieloide Aguda; Animales; Humanos; Ratones; Pez Cebra; Células Madre Hematopoyéticas/metabolismo; Leucemia Mieloide Aguda/tratamiento farmacológico; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patología; Proteínas de Unión al ADN/genética; Dioxigenasas/metabolismo; Proteína Exportina 1

Palabras clave

HSPC; TET2; XPO1; clonal haematopoiesis; eltanexor; selinexor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Dioxigenasas Límite: Animals / Humans Idioma: En Revista: Br J Haematol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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